Sue Patterson, WalletHub Analyst
@sweetsue
No, you cannot use your Home Depot® Credit Card everywhere. The Home Depot® Credit Card is a store credit card and it can only be used at Home Depot stores and through the Home Depot website.
Regular credit cards are part of a card network – Mastercard, Visa, Discover, or American Express – so those cards can be used anywhere the card’s network is accepted. Store cards aren’t affiliated with a card network, so they can only be used in a particular store or set of stores.
Alternative Credit Card Option
If you're in the market for a similar credit card that can be used almost anywhere, check out the Walmart Credit Card. This card is on the Mastercard network, so it's accepted basically anywhere they take credit cards.

Home Depot® Credit Card
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Incorrect, Home Depot credit card payments can indeed be made in-store.