Lisa Cahill, Credit Cards Moderator
@lisacahill
Unfortunately, there is no guarantee you’ll be able to rent a car using a prepaid card, as most major American car rental companies do not accept them as form of payment, and instead require a credit card. The best course of action would be to call the car rental beforehand to ask if they will accept you AmEx Serve card. You may also find details of the policies held by the 10 largest rental companies in the U.S. at: https://wallethub.com/edu/car-rental-without-credit-card/25551/.
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